HORDB

ID: hor001904
Uniprot ID: P04092
Protein name: Glucagon-like peptide 2
Gene name: gcg2
Organism: Lophius americanus (American angler) (Anglerfish)
Family: Glucagon family
Source: Animal
Expression: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
Disease: NA
Comments: NA
Taxonomy: Lophius (genus), Lophiidae (family), Lophioidei (suborder), Lophiiformes (order), Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HADGTYTSDVSSYLQDQAAKDFVSWLKAGRG
Length: 31(89-119)
Propeptide: MTSLHSLAGLLLLMIIQSSWQMPDQDPDRNSMLLNENSMLTEPIEPLNMKRHSEGTFSNDYSKYLETRRAQDFVQWLKNSKRNGLFRRHADGTYTSDVSSYLQDQAAKDFVSWLKAGRGRRE
Signal peptide: MTSLHSLAGLLLLMIIQSSWQ
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P0C0P7-F1.pdb

hor001904_AF2.pdb

hor001904_ESM.pdb

Mass:	390993	Formula:	C148H221N41O50
Absent amino acids:	CEIMNP	Common amino acids:	ADS
pI:	5.54	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	10
Hydrophobicity:	-63.87	Boman Index:	-6237
Half-Life / Aliphatic Index:	3.5 hour	Aliphatic Index:	56.77
Instability Index:	2047.42	Extinction Coefficient cystines:	8480
Absorbance 280nm:	282.67