General Information

  • ID:  hor001904
  • Uniprot ID:  P04092
  • Protein name:  Glucagon-like peptide 2
  • Gene name:  gcg2
  • Organism:  Lophius americanus (American angler) (Anglerfish)
  • Family:  Glucagon family
  • Source:  Animal
  • Expression:  Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lophius (genus), Lophiidae (family), Lophioidei (suborder), Lophiiformes (order), Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0050896 response to stimulus
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HADGTYTSDVSSYLQDQAAKDFVSWLKAGRG
  • Length:  31(89-119)
  • Propeptide:  MTSLHSLAGLLLLMIIQSSWQMPDQDPDRNSMLLNENSMLTEPIEPLNMKRHSEGTFSNDYSKYLETRRAQDFVQWLKNSKRNGLFRRHADGTYTSDVSSYLQDQAAKDFVSWLKAGRGRRE
  • Signal peptide:  MTSLHSLAGLLLLMIIQSSWQ
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P0C0P7-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P0C0P7-F1.pdbhor001904_AF2.pdbhor001904_ESM.pdb

Physical Information

Mass: 390993 Formula: C148H221N41O50
Absent amino acids: CEIMNP Common amino acids: ADS
pI: 5.54 Basic residues: 4
Polar residues: 11 Hydrophobic residues: 10
Hydrophobicity: -63.87 Boman Index: -6237
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 56.77
Instability Index: 2047.42 Extinction Coefficient cystines: 8480
Absorbance 280nm: 282.67

Literature

  • PubMed ID:  NA
  • Title:  NA